Schizophrenia : What inside the brain?

What happens in the brain? If the person who was diagnosis with schizophrenia, the areas of the brain that implicated are the forebrain, hindbrain and limbic system. The reduction in the volume of grey matter especially in temporal and frontal lobes and also the decreased of brain activity in that area. Neurologists also detected the 25% loss of grey matter in some areas of the brain, which started in partial or outer regions of the brain. Furthermore, in 5 years it can spread to the rest of the brain.

Moreover, patients with the worst brain tissue loss can become hallucinations, delusions, bizarre and psychotic thought, hearing voices and depression. Researchs show that neurotransmitters are the causes in the development of schizorphrenia. Overactive dopamine or excessive levels of dopamine can disrupt all aspects of motor, cognitive and emotional functioning which can lead to acute schizophrenia psychosis..


However, according article written by Cazaban A., based on the newer studies indicate that the neurotransmitter serotonin also can cause this symptom. This was discovered through the tests which shown the patients good result with medications that affect the serotonin as well as dopamine.

Thanks to the emerging of new technology, enabled the researchers especially neurologists to study or examine the structure of schizophrenic brains using MRI (Magnetic Resonance Imagery) and MRS (Magnetic Resonance Spectroscopy).




The affected brains were examined and being compared with the normal brain, the findings shown the enlargement of the lateral ventricles, also as stated above, the volume of brain reduced and cerebral cortex become smaller.


Blood circulation also lower in frontal area, whereas temporal lobe structures also become smaller. Not even that area, studies also shown that hippocampus and amygdala reduced in volume. Limbic system which control the mood and emotion and also Superior Temporal Gyrus(STG) involved in language function also notable smaller.